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ABSTRACT Cerebral malaria occurs due to abnormality in the function of the brain endothelium. This signifies that the brain endothelium plays a crucial role in the outcome of malaria in children. Regulated balance between angiopoietin-1 and angiopoeitin-2 is responsible for the control of normal endothelial cell function. The angiopoietin-Tie-2... Continue Reading
ABSTRACT Background: The pathogenesis of cerebral malaria (CM) is still recognized as multifaceted, despite the plausible explanation provided by the high degree of sequestration of parasitized erythrocytes in major organs of the body. Postmortem studies have demonstrated the presence of hemorrhage, deposition of fibrin and clots in blood vessels... Continue Reading
Introduction:Tuberculosis (TB) is a communicable disease that has afflicted man for centuries. It is one of the commonest causes of death from infectious diseases in the world. Nigeria is ranked among the 22 countries with the highest TB burden in the world. The discovery of host or pathogen specific biomarkers of TB for diagnosis, treatment, and... Continue Reading