TABLE OF CONTENTS
DECLARATION ............................................................................................................................. .i
CERTIFICATION .......................................................................................................................... ii
LIST OF ABREVIATIONS ........................................................................................................... vi
LIST OF TABLES ........................................................................................................................ vii
LIST OF FIGURES ..................................................................................................................... viii
ABSTRACT .................................................................................................................................. .ix
CHAPTER ONE: Introduction ........................................................................................................ 1
1.1 Background ................................................................................................................................ 1
1.2 Problem statement ..................................................................................................................... 2
1.3 General objective ....................................................................................................................... 2
1.4 Specific objectives ..................................................................................................................... 2
1.5 Research questions .................................................................................................................... 3
1.6 Justification of the proposed study ............................................................................................ 3
1.7 Significance of the study ........................................................................................................... 3
CHAPTER TWO: Literature review ............................................................................................... 4
2.1 Medicines recommended by WHO in management of typhoid fever ...................................... .4
2.2 Uganda clinical guidelines on management of typhoid fever ................................................... 5
2.3 Health worker factors influencing compliance to typhoid fever treatment guidelines .............. 6
CHAPTER THREE: Methodology ................................................................................................. 7
3.1 Introduction ................................................................................................................................ 7
3 .2 Study design .............................................................................................................................. 7
3 .3 Study setting .............................................................................................................................. 7
3.4 Study population ........................................................................................................................ 7
3.5 Inclusion and exclusion criteria ................................................................................................. ?
iii
3.5.1 Inclusion criteria ..................................................................................................................... ?
3.5.2 Exclusion Criteria ................................................................................................................... 8
3.6 Sample size ................................................................................................................................ 8
3.7 Sampling techniques .................................................................................................................. 9
3.8 Data analysis procedures ........................................................................................................... 9
3.9 Ethical considerations ................................................................................................................ 9
3.10 Limitations to the study ........................................................................................................... 9
CHAPHTER FOUR: Data presentation ........................................................................................ 1 0
4.0 Introduction ............................................................................................................................. 10
4.1 Social demographic findings ................................................................................................... 1 0
4.2 Medicines used in management of typhoid fever .................................................................... 11
4.2.1 Comparing Medicines at KlU-TH with those UCG and WHO guidelines in management of
typhoid fever .................................................................................................................................. 12
4.3 Tests done during diagnosis of typhoid fever .......................................................................... 12
4. 4 Doses and dosage duration of medicines prescribed .............................................................. 13
4.4.1 Comparing doses of medicines prescribed at KIU-TH with those UCG and WHO
guidelines in management of typhoid fever .................................................................................. 14
4.4.2 Comparing dosage duration of medicines prescribed at KlU-TH with those UCG and WHO
guidelines in management of typhoid fever .................................................................................. 15
CHAPTER FIVE ........................................................................................................................... 16
DISCUSSION, CONCLUSION AND RECOMMENDATIONS ................................................. 16
5.0 Introduction ............................................................................................................................. 16
5.1 Discussion of the results ....................................................................................................... 16
5.1 Conclusion ............................................................................................................................ 17
5.1 Recommendations ................................................................................................................ 18
REFERENCES .............................................................................................................................. 19
ABSTRACT Typhoid fever remains a global health problem and it is difficult to estimate the real burden of typhoid fever in the world because the clinical picture is confused with many other febrile infections. Thus this study was aimed assessing health workers' adherence to standard treatment guidelines in the management of typhoid fever in KlU-TH. A retrospective study design was used which was quantitative in nature involving obtaining data from patient files. The study population were patients with typhoid fever attending at KIU-TH and a sample size 60 patients' files was used. Data was collected with help of the data sheet and entered into SPSS version 25, analyzed and presented in form of tables, graphs and pie-charts. The most commonly used medicine to treat typhoid fever was Ciprofloxacin tabs used in 34(56.7%) of the cases in files and the mostly used test for typhoid fever was WAT used in 31(51.7%) files used in this study and 29(48.3%) file cases RDT was used to test for typhoid fever. All cases that used Azithromycin tabs the prescribed dose was 500mg of which 2 cases their dose duration was 3 days and 3 used the dose duration of 5 days. Similarly all the cases where Ciprofloxacin tabs 500mg was the dose, where 26 cases used 10 days as the dose duration and 7 used 14 days as the dose duration. Whereas for Amoxicillin capsules 11 case files used a dose of 500mg and 5 used a dose lg, 6 cases used a dose duration of 5 days, 8 used a dose duration of 10 days and lastly 2 used a dose duration of 14 days. 3 cases that used Cefixine capsules used 1 g as their dose and 2 used 400mg as their dose, 4 used dose duration of 5 days and only 1 used a dose duration of 7 days. In conclusion, all medicines used by health workers that is Ciprofloxacin tablets, Amoxicillin capsules, Azithromycin tablets and Cefixine were recommended by WHO guidelines and UCG. The mostly used medicines was Ciprofloxacin tabs and Ciprofloxacin tablets was properly prescribed by mainly following UCG. Though tests used in diagnosis of typhoid fever that is WAT and RDT were neither recommended by WHO guidelines nor UCG. Regarding doses, all Azithromycin tabs doses were correctly prescribed though 80% of the dose durations were not correct, Cefixine capsule was properly prescribed though 80% of durations were wrong, Amoxicillin capsules doses was properly prescribed using UCG though 43.8% dose durations were wrong according UCG.