Investigation of anti-hyperglyceamic properties of the aqueous extract of green peel of musa acuminata 'naj(jtembe cultivar'

  • Type: Project
  • Department: Pharmaceutical Science
  • Project ID: PHS0077
  • Access Fee: ₦5,000 ($14)
  • Pages: 44 Pages
  • Format: Microsoft Word
  • Views: 204
  • Report This work

For more Info, call us on
+234 8130 686 500
or
+234 8093 423 853

ABSTRACT

The objective of this research was to investigate the anti-hyperglyceamic properties of the aqueous extract green peel of (Banana) musa acuminata 'nakitembe cultivar' in alloxan induced diabetic rats. The extract used was obtaned from the green banana dried and phytochemical analysis and acute toxicity study carried out. Alloxan was used to induce diabetes in experimental albino Rats at a dose of 140mg/kg body weight. After three days, the animals blood sugar levels was tested and those with BS above 7mmol/l were selected for the study. One group was the normal control with normal BS levels. Goup I was normal control treated with nonnal saline, Group II was diabetic control treated with normal saline 2mllkg body weight. Group III and IV recieved extract at a dose of 400 and 800 mg/kg body weight. Group V was treated with standard drug insulin at a dose of 0.03JU/kg body weight. The animals were treated daily and BS was determined every after three days. The project was carried out for 15 days. Blood for testing BS levels was obtained from tail vein. Results ; Phytochemical analysis revealed presence of saponins, tannins, phenols, flavonoids, cardiac glycoside, alkaloids. steroids and terpenoids. The extract showed no signs of toxicity such as salivation, diarrhoea, depression, stimulation, vomiting, and comma and there was no mortality observed up to a dose of 4000mg/kg. Administration of the extract to GROUP III and GROUP IV did not show any significant changes blood sugar levels as compared to that of GROUP V which received the standard :!rug insulin. Conclusion; At the doses investigated, the aqueous extract of the green banana peel did not possess ;ignificant anti-hyperglycemic effect. However it contains phytochemicals which have antioxidant Jropetiies useful in preventing complication brought about by ·glucose toxicity in diabetic patients. The lavonoid content possess significant effect on normalization of serum creatinine level and lowering of -a and relative weight of liver, indicating possible presence of kidney and liver protective propetiy. The ,reen banana peels have an added advantage thus diabetic patients should continue boiling the banana rith the peels. 

Investigation of anti-hyperglyceamic properties of the aqueous extract of green peel of musa acuminata 'naj(jtembe cultivar'
For more Info, call us on
+234 8130 686 500
or
+234 8093 423 853

Share This
  • Type: Project
  • Department: Pharmaceutical Science
  • Project ID: PHS0077
  • Access Fee: ₦5,000 ($14)
  • Pages: 44 Pages
  • Format: Microsoft Word
  • Views: 204

500
Leave a comment...

    Related Works

    ABSTRACT The objective of this research was to investigate the anti-hyperglyceamic properties of the aqueous extract green peel of (Banana) musa acuminata 'nakitembe cultivar' in alloxan induced diabetic rats. The extract used was obtaned from the green banana dried and phytochemical analysis and acute toxicity study carried out. Alloxan was... Continue Reading
    ABSTRACT Ibuprofen, a strong analgesic and an anti-inflammatory drug used over a long period caused side effects such as peptic ulcer and constipation. Honeydew melon has been shown to possess anti-secretory, antiulcer and angiogenic. Hence, this study investigated the anti-ulcer effect of aqueous extract of honeydew melon on ibuprofen induced... Continue Reading
    ABSTRACT Musa paradisiaca is mainly grown in the tropical and subtropical countries and widely used for its nutritional values all over the world. The fruit as well as the peels and leaves are used to treat different diseases in human in traditional medicine. This study presents the mineral compositions and antifungal activity of ethanol... Continue Reading
    ABSTRACT Musa paradisiaca is mainly grown in the tropical and subtropical countries and widely used for its nutritional values all over the world. The fruit as well as the peels and leaves are used to treat different diseases in human in traditional medicine. This study presents the mineral compositions and antifungal activity of ethanol... Continue Reading
    ABSTRACT Erlangea tomentosa is been used traditionally in the management of several diseases including pain and inflammation. However, their efficacy has not been scientifically validated. The aim of this study therefore is to investigate the analgesic and anti-inflammatory activities of the aqueous leaf extract. The plant materials were collected... Continue Reading
    ABSTRACT Aim: To evaluate the anti-diabetic effect of aqueous extract of Saccharum officinarum (stem bark) in the genomic DNA of diabetic Wistar rats. Methodology: 15 Streptozotocin-induced diabetic male rats and five non diabetic rats were randomly and evenly distributed into four groups, and were subsequently exposed to the following treatments... Continue Reading
    ABSTRACT Aim: To evaluate the anti-diabetic effect of aqueous extract of Saccharum officinarum (stem bark) in the genomic DNA of diabetic Wistar rats. Methodology: 15 Streptozotocin-induced diabetic male rats and five non diabetic rats were randomly and evenly distributed into four groups, and were subsequently exposed to the following treatments... Continue Reading
    Anti-diabetic and Anti-oxidant potentials of Aqueous Extract of Eucalyptus Globulus in experimentally induced diabetic rats.... Continue Reading
    Anti-diabetic and Anti-oxidant potentials of Aqueous Extract of Eucalyptus Globulus in experimentally induced diabetic rats.... Continue Reading
    ABSTRACT This research investigated the phytochemical and anti-inflammatory properties of methanol extract of Crateva adansonii stem bark. Although several edible and non-edible plants parts are used in inflammatory treatment, many record has been found of the use of Crateva adansonii stem bark. For this research, fresh stem bark of Crateva... Continue Reading
    Call Us Get this work