ABSTRACT
Nickel amine carboxylate complexes were synthesized by reacting Ni(ii)chloride with ammonia, malonic and tartaric acid, which formed Nickel amine malonate and Nickel amine tartarate of blue and green crystal and the percentage yield are of both complexes are 62.65% and 62.83% respectively. The decomposition temperatures were 218o C and 203oC with percentage moisture content of 8.0% and 21.50%. The carboxylic acids and the synthesized complexes were tested for antibacterial activity on Escherichia coli at concentrations of 5mg, 10mg, and 15mg.The zone of inhibition given by the complexes were 35mm,40mm,48mm for the malonate complex and 31mm, 37mm and 42mm for the tartarate complex. In the infrared spectra the presence of M-N, M-O and C-H bonding revealed the bonding of the metal ion to the ligands to form complexes.
Table of Content
CHAPTER ONE
1.0Introduction1
1.1Transition elements1
1.2Complex compound2
1.3Ligand5
1.4Antibacterial property6
1.5Statement of problem¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬ 8
1.6Justification8
1.7Aim and objectives9
1.8Scope9
CHAPTER TWO
2.0 Literature review10
2.1Nickel complexes11
2.2Nickel amine complexes13
2.3Amine carboxylate complexes17
2.4Antibacterial application 20
CHAPTER THREE
3.0Methodology24
3.1Materials 24
3.2Synthesis of nickel amine carboxylate complexes 24
3.2.1Synthesis of nickel amine malonate24
3.2.2Synthesis of nickel amine tartarate25
3.3Characterization of nickel amine carboxylate complexes25
3.3.1Physical properties 25
3.3.2Solubility test 25
3.3.3Melting point 26
3.3.4Determination of moisture content26
3.3.5 Infrared spectroscopy analysis 26
3.4.Antibacterial activity 26
CHAPTER FOUR
4.0Results28
CHAPTER FIVE
5.0Discussion32
5.1Conclusion33
5.2Recommendations33
Reference34
Appendix IA36
Appendix IB38
Appendix II40
LIST OF TABLES
Table 4.1 Percentage Yield of the complexes 28
Table 4.2 Physical properties of the complexes28
Table 4.3Solubility test29
Table 4.4Antibacterial Activity of the compounds 30
Table 4.5Infrared spectral data of the complexes31