The Human Immune Response to Plasmodium falciparum Includes Both Antibodies That Inhibit Merozoite Surface Protein 1 Secondary Processing and Blocking Antibodies
The Human Immune Response to Plasmodium falciparum Includes Both Antibodies That Inhibit Merozoite Surface Protein 1 Secondary Processing and Blocking Antibodies
Malaria merozoite surface protein 1 (MSP1) is cleaved in an essential step during erythrocyte invasion. The responses of children to natural malaria infection included antibodies that inhibit this cleavage and others that block the binding of these inhibitory antibodies. There was no correlation between the titer of the antibody to the 19-kDa fragment of MSP1 and its inhibitory activity. These findings have implications for the design of MSP1-based vaccines.
The Human Immune Response to Plasmodium falciparum Includes Both Antibodies That Inhibit Merozoite Surface Protein 1 Secondary Processing and Blocking Antibodies
Abstract Malaria remains a major parasitic disease in Africa, with 300–500 million new infections each year. There is therefore an urgent need for the development of new effective measures, including vaccines. Plasmodium falciparum merozoite surface protein-119 (MSP-119) is a prime candidate for a blood-stage malaria vaccine. Blood samples were... Continue Reading
Abstract Malaria remains a major parasitic disease in Africa, with 300–500 million new infections each year. There is therefore an urgent need for the development of new effective measures, including vaccines. Plasmodium falciparum merozoite surface protein-119 (MSP-119) is a prime candidate for a blood-stage malaria vaccine. Blood samples were... Continue Reading
ABSTRACT The suitability o f five Schistosoma genus-specific monoclonal antibodies (MoAbs) (Sh3/34.10, Sh3/38.2, Sh4/14.3, Sh5/32.30 and Sh5/34.10) in detecting schistosome antigens in infected human and cattle was evaluated. These antibodies were employed in various diagnostic assays to diagnose human and animal schistosomiasis. Extant MoAb... Continue Reading
ABSTRACT seroprevalence study of Brucella abortus antibodies was carried out in cattle and humans in Taraba State. The aim of the study was to determine the current status of B.abortus in cattle and humans and to find the distribution of the infection with respect to settled and nomadic herds, sex, breed, live and slaughtered cattle, geographical... Continue Reading
TABLE OF CONTENTS CHAPTER ONE 1.0 INTRODUCTION CHAPTER TWO 2.0 LITERATURE REVIEW CHAPTER THREE 3.0 MATERIALS AND METHODS 3.1 SAMPLE COLLECTION 3.1.1 STERILIZATION OF MATERIALS 3.1.2 PREPARATION OF ERYTHROCYTE FOR HAEMAGGLUTINATION INHIBITION TEST (CHICKEN RED BLOOD CELL) 3.1.3 HAEMAGGLUTINATION ASSAY FOR (STOCK ANTIGEN)... Continue Reading
TABLE OF CONTENTS CHAPTER ONE 1.0 INTRODUCTION CHAPTER TWO 2.0 LITERATURE REVIEW CHAPTER THREE 3.0 MATERIALS AND METHODS 3.1 SAMPLE COLLECTION 3.1.1 STERILIZATION OF MATERIALS 3.1.2 PREPARATION OF ERYTHROCYTE FOR HAEMAGGLUTINATION INHIBITION TEST (CHICKEN RED BLOOD CELL) 3.1.3 HAEMAGGLUTINATION ASSAY FOR (STOCK ANTIGEN) 3.1.4 HAEMAGGLUTINATION... Continue Reading
ABSTRACT Prevalence and distribution of bluetongue virus (BTV) antibodies in sheep and goats in Sokoto State are reported. This study aimed to determine the prevalence of BTV antibodies and to identify the potential risk factors associated with BTV infection among sheep and goats in Sokoto State, Nigeria. A total of 368 blood samples were... Continue Reading
Abstract Schistosomiasis is an economically important disease of man and livestock caused by trematode parasites of the genus Schistosoma. The disease is wide-spread and endemic throughout many parts of the world infested by the intermediate freshwater snail hosts belonging to the family Planorbidae. The affected areas include; Africa, Madagascar,... Continue Reading
ABSTRACT Prevalence and distribution of bluetongue virus (BTV) antibodies in sheep and goats in Sokoto State are reported. This study aimed to determine the prevalence of BTV antibodies and to identify the potential risk factors associated with BTV infection among sheep and goats in Sokoto State, Nigeria. A total of 368 blood samples were... Continue Reading
ABSTRACT Current efforts to eliminate malaria worldwide are soaring and one of the approaches to this is the mass screening of medicinal plants for their possible potential anti-malarial property. The current study conducted was to determine the effect of one such plant, Cryptolepis sanguinolenta on gametocyte development. In vitro growth... Continue Reading